Kidney Disease in Dogs and Cats Often Described as Incurable Research on the field, "Canine Toxicology," published in a peer-reviewed journal

15 years of ongoing research efforts on canine and feline kidneys

2026.01.20 09:00

林技研株式会社

Hayashi Giken Co. (Head office: Shinjuku-ku, Tokyo; President: Motohiro Hayashi) announces that a research paper on the plant material Angelica shikokiana, which the company researches and handles, has been published in the January 2026 issue of the peer-reviewed academic journal New Food Industry. New Food Industry (January 2026).

This study examined the relationship between canine tokki intake and renal function indices in dogs and cats by analyzing blood test data obtained within the scope of routine medical care.

『New Food Industry』1月号表紙

Cover of the January issue of New Food Industry

Social Background Surrounding Pets and the Issue of Kidney Disease

In recent years, the number of pet owners in Japan has been increasing, while awareness of pets as "family members" has been spreading and interest in medical care and health management has been growing year by year. At the same time, the pet population is aging, and chronic diseases associated with aging are becoming a social issue.

In cats in particular, kidney disease is known to be one of the leading causes of death, pointing to the importance of early recognition and ongoing health management. However, kidney disease is a disease that is often noticed only after an examination because there are few apparent changes in the early stages of the disease.

Purpose and Background of the Research

Hayashi Giken Co., Ltd. has long been conducting research on kidney function in dogs and cats based on an awareness of these issues. The company's research is not limited to the study of specific materials, but aims to grasp the overall picture of "how to deal with kidney disease" from the perspective of evaluation methods for early detection of kidney disease, consideration of indicators that can be used in daily health management, and provision of information to make it easier for owners to notice any abnormalities.

The research on inutouki (dogtooth viper) published in this issue is positioned as a part of this effort.

■Summary of the Study and Contents of the Report

In this study, blood test data obtained within the scope of routine medical care were analyzed in dogs and cats.

Focusing on changes in BUN (blood urea nitrogen) and creatinine (Cr), which are used as indices for evaluating renal function, the study examines the relationship between the intake of canine toki and these indices.

The paper reports the following points

(1) A continuous evaluation of inutouki intake was conducted.

　 The paper states that continuous evaluation for at least 90 days is desirable.

(2)That significant changes have been reported, especially in IRIS stage 1 and 2 cases in cats, regarding changes in BUN and Cr.

　 (2) Significant changes in BUN and Cr trends have been reported, especially in feline IRIS stage 1 and 2 patients.

These results are discussed as providing suggestions for maintenance and support of renal function.

■Study Conditions

The main research conditions described in the paper are as follows

Target animals: Dogs and cats

Recommended dosage: Approximately 0.1 g/day per 3 kg body weight

Method of administration: Mixed with food

Period of use: Evaluation based on the assumption of continuous use

Data ： Examination data obtained within the scope of daily medical care

These are the conditions actually used in the research.

Characteristics of Research Activities by a Small Organization

Hayashi Giken Co., Ltd. is a small organization with only a few employees, although it operates several businesses, including a construction division, a Ulyseed division (chiro salon business), and a pet wellness division.

One of the company's unique features is its relatively unusual organizational structure, in that all of its employees and bond purchasers who support its research activities are customers of the Ulyseed chiro salon.

A portion of the company's research funds are collected in the form of bonds, which are not merely an investment, but have been supported by the empathy and trust of customers who want the company to continue this research.

Against this background, one of the characteristics of the company's research activities is that they strongly reflect not only the viewpoints of researchers, but also those of people who have actually faced health and physical problems.

■Information dissemination and future development

Under the brand name "JIN Katsudo Kenkyujo," the company disseminates information on health management and kidney disease in cats and dogs through media such as Ameblo, Instagram, YouTube, and LINE.

These information dissemination efforts are not intended as one-way communication of research results, but rather as a place to share knowledge accumulated through dialogue with customers and supporters.

The company plans to continue its efforts to maintain the health of pets by connecting the perspectives of research, the field, and consumers.

■Supplemental Information (Important)

This research and related products are not intended for the diagnosis, treatment, or prevention of disease.

*When using the products, please understand that they are not a substitute for veterinary diagnosis and treatment.

Journal Information

Journal name: New Food Industry

Issue: January 2026

Description: Research report on canine toki for dogs and cats

URL: https://nfi-llc.securesite.jp/nfi/2026-1/2026-1.pdf

Company Profile

Company name: Hayashi Giken Co.

Business description: Construction, chiropractic salon business (Ulyseed), pet wellness business